|
KMID : 0356820030190010021
|
|
Korean Journal of Head & Neck Oncology
2003 Volume.19 No. 1 p.21 ~ p.24
|
|
|
Distribution Patterns in the Tumor Tissue and Normal Tissue according to the Administration Methods of ALA and ALA-Methylester
|
|
정필상
정상운/안진철/이상준/윤준식
|
|
|
Abstract
|
|
|
Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region.
Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer).
Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region.
Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|